Fred Hutch biostatisticians and UW faculty members Holly Janes and Peter Gilbert spoke with NPR about new evidence that points to antibodies as a reliable indicator of vaccine protection. David Benkeser (PhD, '15) is also quoted.
Alumni in the News
![Healthcare professional readies a Moderna COVID-19 dose for patient.](/sites/default/files/styles/news_image_mobile_thumb/public/2021-08/im10col-covid-19-vaccine.jpeg?itok=tNNxgSy7)
![Healthcare professional readies a Moderna COVID-19 dose for patient.](/sites/default/files/styles/news_image_thumb/public/2021-08/im10col-covid-19-vaccine.jpeg?itok=bpTYSfYt)
In the race to develop new and better vaccines and boosters to block COVID-19, scientists are eagerly seeking laboratory tests that can measure immune responses to quickly show how well these shots are working, instead of waiting months for results of clinical trials involving tens of thousands of people.
Now, a group of top scientists, including Dr. Peter Gilbert, a biostatistician at Seattle’s Fred Hutchinson Cancer Research Center, are reporting that they have defined such measurements — or correlates of protection — for the widely used Moderna mRNA vaccine.
![Close up of hand holding bottle of Moderna COVID-19 vaccube](/sites/default/files/styles/news_image_mobile_thumb/public/2021-08/22OWFJ6I6JPYFJZFDCRYFP5CEU.jpg?itok=bdsD1q1b)
![Close up of hand holding bottle of Moderna COVID-19 vaccube](/sites/default/files/styles/news_image_thumb/public/2021-08/22OWFJ6I6JPYFJZFDCRYFP5CEU.jpg?itok=TKCPmDqo)
Finding a surrogate measure of efficacy should speed regulators' decisions on vaccine approval even without large placebo-controlled studies, which could be impracticable to carry out if vaccines become widely available, said Peter Gilbert, a researcher at Fred Hutchinson and an author of the recent study.
![Peter Gilbert](/sites/default/files/styles/news_image_mobile_thumb/public/2020-01/peter-gilbert.jpg?itok=D4D4tpVY)
![Peter Gilbert](/sites/default/files/styles/news_image_thumb/public/2020-01/peter-gilbert.jpg?itok=f1ALrU0B)
Eagerly anticipated new research pinpoints antibodies scientists can test for to see if a COVID-19 vaccine is effective. These "correlates of protection" could speed the development of new vaccines or boosters without requiring the enormous clinical trials used to create the first COVID-19 vaccines. This is "the Holy Grail" in terms of vaccines, and one that hasn't yet been set for the virus that causes COVID-19, said Peter Gilbert, co-author of the study posted August 10 to medRxiv and a UW research professor of biostatistics.
Fred Hutch researcher and UW Biostatistics alum Elizabeth Krantz (MS, '00) co-led a project that examined how much protection cancer patients have against measles and mumps. "Our findings really emphasize the need to increase immunity at the community level, particularly among health care workers or caregivers who have frequent contact with cancer patients."
![Photo of Yingye Zheng and Thomas Braun](/sites/default/files/styles/news_image_mobile_thumb/public/2021-05/asa-fellows-2021_0.jpg?itok=HMgnT-Hq)
![Photo of Yingye Zheng and Thomas Braun](/sites/default/files/styles/news_image_thumb/public/2021-05/asa-fellows-2021_0.jpg?itok=2RPLd9Ua)
![Peter Gilbert](/sites/default/files/styles/news_image_mobile_thumb/public/2020-01/peter-gilbert.jpg?itok=D4D4tpVY)
![Peter Gilbert](/sites/default/files/styles/news_image_thumb/public/2020-01/peter-gilbert.jpg?itok=f1ALrU0B)
"Think of the vaccine as a sieve and different variants as pebbles poured into the sieve: the vaccine will block some variants but allow others to pass through, and sieve analysis learns which variants make it through." — Peter Gilbert, biostatistician at the Fred Hutch Vaccine and Infectious Disease and Public Health Sciences Divisions and a UW research professor of biostatistics.
![Headshot of Holly Janes](/sites/default/files/styles/news_image_mobile_thumb/public/2021-03/holly-janes%2520hutch_0.jpg?itok=hWdz5si2)
![Headshot of Holly Janes](/sites/default/files/styles/news_image_thumb/public/2021-03/holly-janes%2520hutch_0.jpg?itok=oIELBtXL)
![Photo of Garnet Anderson in front of Fred Hutch logo](/sites/default/files/styles/news_image_mobile_thumb/public/2021-03/Garnet%2520Anderson%2520Hutch%2520Photo.jpeg?itok=eNQbwyW9)
![Photo of Garnet Anderson in front of Fred Hutch logo](/sites/default/files/styles/news_image_thumb/public/2021-03/Garnet%2520Anderson%2520Hutch%2520Photo.jpeg?itok=-HNOzOCM)
“The WHI has been remarkably productive in pursuing a broad range of scientific questions important to women,” said Garnet Anderson (PhD ’89) director of the Hutch's Public Health Sciences division and principal investigator of the Women’s Health Initiative (WHI) clinical coordinating center. Anderson is also an affiliate professor of biostatistics with the University of Washington School of Public Health.
![Photos of Peter Gilbert and Holly Janes](/sites/default/files/styles/news_image_mobile_thumb/public/2021-02/Gilbert_Janes%2520photo.croppedjpg.jpg?itok=ijGhGdXB)
![Photos of Peter Gilbert and Holly Janes](/sites/default/files/styles/news_image_thumb/public/2021-02/Gilbert_Janes%2520photo.croppedjpg.jpg?itok=8Lu2DpKA)
When COVID-19 burst onto the scene last winter, and Tony Fauci, head of the National Institute of Allergy and Infectious Diseases, was looking for a way to run massive, credible and rigorous trials of potential vaccines, he turned to experts at the HIV Vaccine Trials Network (HVTN) based at the Fred Hutchinson Cancer Research Center. Co-principal investigators of the HVTN Statistics and Data Management Center include three researchers who are also University of Washington School of Public Health faculty: Peter Gilbert (Biostat), Holly Janes (Biostat), and Yunda Huang (Global Health).