Three-Way Identity-by-Descent Approach Refines Average Genome-Wide Mutation Rate for Humans

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Researchers have used a new approach to refine the estimate of the average genome-wide mutation rate for humans, which they pegged at 1.24 x 10-8 per base pair per generation.

According to UW Professor of Biostatistics Sharon Browning and her colleagues, the rate they calculated "is consistent with our previous IBD-based estimates but has tighter confidence intervals because of the larger sample size enabled by the methodology presented here."

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